Clinical Evidence

ATTUNE Knee Evidence Summaries

ATTUNE Knee System Evidence Brochure

The ATTUNE Knee System evidence demonstrates how the ATTUNE Knee addresses challenges in TKA, such as crepitus, patient satisfaction, stability, implant survivorship and fixation.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

ATTUNE Knee Patellofemoral Overview

Improved Patellofemoral outcomes with the ATTUNE Knee consistently demonstrated across four independent studies.

ATTUNE Knee Evidence Visual Aid

Overview covers early evidence on implant survivorship, patient-reported outcomes and health economics.

Patient Reported Outcome Measures

Early Outcomes with a New Primary TKA System vs. Contemporary TKA Interim Results of Two Worldwide Multi-Center Prospective Studies

At 1 yr. compared to patients implanted with other leading knee brands, PROMS reported by ATTUNE Knee patients were statistically significantly better or trended to favor ATTUNE Knee patients.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

Joint Registry Data and Implant Survivorship Studies

Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI)

Registry data from Michigan (United States) results demonstrating ATTUNE Knee implant survivorship in line with the class of TKA.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

NJR Implant Summary Report for ATTUNE Knee CR and PS, May 2018 Report

National Joint Registry for England, Wales, Northern Ireland and the Isle of Man. Implant Summary Report for DePuy ATTUNE CR and ATTUNE PS. NJR Database extract May 4, 2018, pages 1-15. Licensed for use until September 11, 2018. Available at www.attuneevidence.com (US) and www.provingthepromise.com (EMEA).

Kaiser Permanente Total Joint Registry

The ATTUNE Knee System demonstrated low (<2%) cumulative revision rate at 2 years in the Kaiser Permanente Total Joint Registry (United States).

ATTUNE Knee Improved Survivorship Clinical Outcomes P.F.C. SIGMA Knee

ATTUNE Knee System has significantly improved implant survivorship over P.F.C. SIGMA Knee at short-term follow up.

NJR Implant Summary Report Presentation

This presentation demonstrates four year results for the ATTUNE Knee System in the NJR Implant Summary Report for ATTUNE CR Knee and ATTUNE PS Knee. Database extract July 30, 2018, pages 1-15. Licensed for use until December 11, 2018.

OANJRR Automated Industry Report (AIRS) ATTUNE Knee CR

Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR), Automated Industry Report System (AIRS), ID No. 334 for DePuy Synthes, ATTUNE CR/ATTUNE Total Knee. (Procedures from 1 September 1999 – 17 August 2018). Accessed 20 August 2018, AOA, Adelaide: 1-13.

AOANJRR Automated Industry Report (AIRS) ATTUNE Knee PS

Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR), Automated Industry Report System (AIRS), ID No. 335 for DePuy Synthes, ATTUNE Cps/ATTUNE Total Knee. (Procedures from 1 September 1999 – 17 August 2018). Accessed 20 August 2018, AOA, Adelaide: 1-13.

AIRS ATTUNE Knee CR/PS Report Presentation

Additional survivorship data is now available to manufacturers who subscribe to the AOANJRR's Automated Industry Report System (AIRS). This presentation is from the AOANJRR AIRS for CR and PS ATTUNE Knees, produced on August 20th, 2018, with data through August 17th, 2018. 

Health Economics Data

Hospital Length of Stay and Discharge Disposition after Primary Total Knee Arthroplasty

85% of the ATTUNE Knee patients were discharged in 3 days or less and 79% of ATTUNE Knee patients were discharged to home with or without home healthcare while 21% were discharged to Skilled Nursing Facility or other facilities.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee system in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

April 2017 Orthopedics Today ATTUNE Knee Supplement

Four new articles that review the early outcomes of several studies, highlights the elements of the implant design that contribute to clinical performance, as well as evaluates how the ATTUNE Knee may impact health economics in the bundled payment environment. Featured authors include Ryan Nunley, MD, Sean Toomey, MD, Mark Clatworthy, MD, and Keven Shelburne, PhD.

The Impact of Implant Design on Hospital Length of Stay and Discharge Destination

Five studies demonstrate that the ATTUNE Knee may positively impact patient length of stay (LOS) following TKA. All the observed LOS reductions in these studies were statistically significant.

Early User Studies

ATTUNE Knee Improved Survivorship Clinical Outcomes P.F.C. SIGMA Knee

ATTUNE Knee System has significantly improved implant survivorship over P.F.C. SIGMA Knee at short-term follow up.

An Early Outcome Study of the ATTUNE Knee System vs. the SIGMA® CR150 Knee System

ATTUNE Knee patients have less pain, better motion and improved function in this short-term follow up study.

ATTUNE Knee System Early Performance: Minimum Two Year Clinical Results White Paper

ATTUNE Knee early performance registry demonstrated satisfactory early clinical results and the 2 year implant survivorship estimate was 99.49%.

 

 

References

1. Indelli P.F., Pipino G., Johnson P., Graceffa A., Marcucci M. Posterior-stabilized total knee arthroplasty: a matched pair analysis of a classic and its evolutional design. Arthroplasty Today 2016; 206,2(4):193-1986. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

2. Ranawat C.S., White P.B., West S., Ranawat A.S., Clinical and Radiographic Results of Attune and PFC Sigma Knee Designs at 2-Year Follow-Up: A Prospective Matched-Pair Analysis. J Arthroplasty 2017;32:431-6. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

3. Martin J.R., Jennings J.M., Watters T.S., Levy D.L., McNabb D.C., Dennis D.A. Femoral Implant Design Modification Decreases the Incidence of Patellar Crepitus in Total Knee Arthroplasty. J Arthroplasty. 2017 Apr;32(4):1310-1313. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

4.Toomey, S.D., Daccach, J., Shah, J., Himden, S., Lesko, J., Hamilton W.G.: Comparative Incidence of Patellofemoral Complications Between Two Total Knee Arthroplasty Systems in a Multi-Center, Prospective Clinical Study. J Arthroplasty, available online, April 2017. Implants tested: P.F.C. SIGMA (DePuy)

5. Hamilton W.G., Brenkel, I., Clatworthy, M., Dwyer, K,. Himden, S., Lesko, J., Kantor, S. Early Outcomes with a New Primary TKA System vs. Contemporary TKA: Interim Results of Two Worldwide, Multi-Center Prospective Studies. AAOS, San Diego, California, March 14-18, 2017. Other implants tested: SIGMA Knee (DePuy), NexGen® (Zimmer), Triathlon® (Stryker)

6. Clatworthy, M. (2015). An Early Outcome Study of the ATTUNE Knee System vs. the SIGMA® CR150 Knee System. DePuy Synthes Companies White Paper. DSUS/JRC/0814/0418(1). In an IRB approved early outcomes study, physiotherapists collected data on 40 patients implanted with ATTUNE® Knees and 40 patients with SIGMA®CR150 knees. The results demonstrated that patients implanted with the ATTUNE Knee had statistically significant improvements in some early outcomes, other outcomes demonstrated a trend favoring the ATTUNE Knee, and some outcomes were equivalent.

7. Etter, K., Lerner, J., de Moor, C, Yoo, A., Kalsekar, I. (2016). PMD10-Comparative Effectiveness of ATTUNE® Versus TriathlonTM Total Knee Systems: Real-World Length of Stay and Discharge Status.”Value in Health 19(3): A298. Premier PerspectiveTM Database analysis including 38 hospitals, representing 1,178 primary, unilateral TKAs with the ATTUNE Knee and 5,707 primary, unilateral TKAs with TriathlonTM. The analysis found that the patients implanted with the ATTUNE Knee had statistically shorter length of stay and were more frequently discharged home vs. a skilled nursing facility compared to the TKAs with TriathlonTM.

 

The ATTUNE Knee System is backed by a comprehensive evidence generation program that encompasses clinical and patient reported outcomes (PROMS) as well as value based healthcare studies.

The early clinical results of the ATTUNE Knee are promising and include data from national registries, company initiated, independent studies, and investigator initiated studies, as noted in the articles and papers.

 

All medical devices have associated risks. Please refer to the instructions for use and other labeling for a complete list of indications, contraindications, precautions and warnings.

For further information on DePuy Synthes products, please contact your local DePuy Synthes Representative .

 

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