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See what these surgeons are saying about how the ATTUNE® Knee helps patients get back to what they love sooner.6,7

Helping Sooner

Dr. Barrett discusses how today’s TKA patients are able to get back to their activities sooner.6,7

Stability and Motion

Surgeons share their experiences with the ATTUNE® Knee.

Patient Outcomes

Dr. Nunley has observed positive outcomes over 3.5 years using the ATTUNE Knee.

Recovery Time

Patients with the ATTUNE® Knee are able to get back to what they love sooner.6,7

ATTUNE Knee Evidence Summaries

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ATTUNE Knee System Evidence Summary

The ATTUNE Knee System evidence demonstrates how the ATTUNE Knee addresses challenges in TKA, such as crepitus, patient satisfaction, stability, implant survivorship and fixation.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

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ATTUNE Knee Patellofemoral Overview

Improved Patellofemoral outcomes with the ATTUNE Knee consistently demonstrated across four independent studies.

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ATTUNE Knee Evidence Visual Aid

Overview covers early evidence on implant survivorship, patient-reported outcomes and health economics.

Patient Reported Outcome Measures

NEW-TKA System (new Total Knee Arthroplasty System) exhibited a trend toward improved outcomes across a broad range of PROMs (patient reported outcomes) compared to currently available TKA implant designs.

Early Outcomes with a New Primary TKA System vs. Contemporary TKA Interim Results of Two Worldwide Multi-Center Prospective Studies

At 1 yr. compared to patients implanted with other leading knee brands, PROMS reported by ATTUNE Knee patients were statistically significantly better or trended to favor ATTUNE Knee patients.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

Joint Registry Data and Implant Survivorship Studies

Michigan Arthroplasty Registry - asset

Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI)

Registry data from Michigan (United States) results demonstrating ATTUNE Knee implant survivorship in line with the class of TKA.

Parkin Fisher white paper that summarizes the burden of osteoarthritis, primary TKA (Total Knee Arthroplasty) as a treatment option for those patients, approaches for evaluating TKA from a clinical and health economic perspective, and assess the available data on the primary ATTUNE® Knee. Early clinical results with the ATTUNE Knee provide insights into how this knee implant could help provide value as demonstrated by survivorship, improved patient reported outcomes scores and reduced secondary procedures for complications such as patellofemoral pain.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee System in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

Parkin Fisher white paper that summarizes the burden of osteoarthritis, primary TKA (Total Knee Arthroplasty) as a treatment option for those patients, approaches for evaluating TKA from a clinical and health economic perspective, and assess the available data on the primary ATTUNE® Knee. Early clinical results with the ATTUNE Knee provide insights into how this knee implant could help provide value as demonstrated by survivorship, improved patient reported outcomes scores and reduced secondary procedures for complications such as patellofemoral pain.

NJR Implant Summary Report for ATTUNE Knee CR and PS, May 2018 Report

National Joint Registry for England, Wales, Northern Ireland and the Isle of Man. Implant Summary Report for DePuy ATTUNE CR and ATTUNE PS. NJR Database extract May 4, 2018, pages 1-15. Licensed for use until September 11, 2018. Available at www.attuneevidence.com (US) and www.provingthepromise.com (EMEA).

Kaiser Permanente Total Joint Registry

Kaiser Permanente Total Joint Registry

The ATTUNE Knee System demonstrated low (<2%) cumulative revision rate at 2 years in the Kaiser Permanente Total Joint Registry (United States).

ATTUNE Knee Improved Survivorship Clinical Outcomes P.F.C. SIGMA Knee

ATTUNE Knee Improved Survivorship Clinical Outcomes P.F.C. SIGMA Knee

ATTUNE Knee System has significantly improved implant survivorship over P.F.C. SIGMA Knee at short-term follow up.

Health Economics Data

A real-world analysis evaluating the LOS (Length of Stay) and discharge status for 1,766 patients who had the ATTUNE Knee System implanted during TKA (Total Knee Arthroplasty).

Hospital Length of Stay and Discharge Disposition after Primary Total Knee Arthroplasty

85% of the ATTUNE Knee patients were discharged in 3 days or less and 79% of ATTUNE Knee patients were discharged to home with or without home healthcare while 21% were discharged to Skilled Nursing Facility or other facilities.

Parkin Fisher white paper that summarizes the burden of osteoarthritis, primary TKA (Total Knee Arthroplasty) as a treatment option for those patients, approaches for evaluating TKA from a clinical and health economic perspective, and assess the available data on the primary ATTUNE® Knee. Early clinical results with the ATTUNE Knee provide insights into how this knee implant could help provide value as demonstrated by survivorship, improved patient reported outcomes scores and reduced secondary procedures for complications such as patellofemoral pain.

Improving the Value of Primary Total Knee Arthroplasty: The ATTUNE Knee System

Report demonstrates the clinical and economic value of the ATTUNE Knee system in today’s value-based environment: implant survivorship, economic and patient reported data are needed to measure outcomes and cost benefits.

The ATTUNE Knee System was designed to provide more stability with fewer patellofemoral complications, with improved patient outcomes as the main goal. The device was also designed to be easier to implant than contemporary total knee systems. Featured authors include Ryan Nunley, MD, Sean Toomey, MD, Mark Clatworthy, MD, and Kevin Shelburne, PhD.

April 2017 Orthopedics Today ATTUNE Knee Supplement

Four new articles that review the early outcomes of several studies, highlights the elements of the implant design that contribute to clinical performance, as well as evaluates how the ATTUNE Knee may impact health economics in the bundled payment environment. Featured authors include Ryan Nunley, MD, Sean Toomey, MD, Mark Clatworthy, MD, and Keven Shelburne, PhD.

Impact of Implant Design on Hospital Length of Stay - asset

The Impact of Implant Design on Hospital Length of Stay and Discharge Destination

Five studies demonstrate that the ATTUNE Knee may positively impact patient length of stay (LOS) following TKA. All the observed LOS reductions in these studies were statistically significant.

Early User Studies

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ATTUNE Knee Improved Survivorship Clinical Outcomes P.F.C. SIGMA Knee

ATTUNE Knee System has significantly improved implant survivorship over P.F.C. SIGMA Knee at short-term follow up.

This is an early outcome study of a series of 40 ATTUNE® Knee patients & 40 SIGMA® CR150 Knee patients. Patients who received the ATTUNE Knee System had less pain, better motion & function in the early post-operative phase when compared with the surgeon’s previous knee of choice (SIGMA CR150 Knee).

An Early Outcome Study of the ATTUNE Knee System vs. the SIGMA® CR150 Knee System

ATTUNE Knee patients have less pain, better motion and improved function in this short-term follow up study.

The ATTUNE® Knee Early Performance Registry demonstrated satisfactory early clinical results for the ATTUNE Knee System. Overall, there was a marked improvement in outcomes as demonstrated by the positive change from baseline scores. The 2-year survivorship estimate for the ATTUNE Knee Early Performance Registry was 99.49% at 2 years.

ATTUNE Knee System Early Performance: Minimum Two Year Clinical Results White Paper

ATTUNE Knee early performance registry demonstrated satisfactory early clinical results and the 2 year implant survivorship estimate was 99.49%.

A 2000 patient assessment that evaluates the learning curve associated with a new TKA (Total Knee Arthroplasty) design (implant & instruments) & compare PROMs (patient reported outcome measures) demonstrated there was no difference in knee-related intraoperative complications & the surgical time learning curve was mild.

Learning Curve with a New Primary TKA Implant: A Worldwide Perspective with more than 2000 Patients

Assessment of learning curve (early vs. later cases) demonstrated no difference in knee-related intraoperative complications, no difference in PROMS and surgical time learning curve was mild.

Scientific Evidence

Product Information

SOFCAM™ Contact was developed after exhaustive testing to help address challenges with PS (posterior cruciate substituting) Knees for TKA (total knee arthroplasty) designs. SOFCAM™ Contact (cam & spine shape, location, & intercondylar box geometry) was designed with the goal of creating optimized cam-spine mechanics for a wide range of patient anatomies.

ATTUNE Knee System – SOFCAMTM White Paper

 

Anterior knee pain following TKR (total knee replacement) remains a common occurrence for some patients, leading to decreased mobility & patient satisfaction. In the ATTUNE® Knee development program, considerable progress has been made in understanding patella-femoral kinematics with innovative experimental & computer software techniques for TKR patients. This has led to the design of a physiological trochlear groove and patella resurfacing options to more accurately mimic natural patello-femoral function & performance.

ATTUNE Knee System - GLIDERIGHT Articulation

 

When testing 10mm thick overall constructs, the ATTUNE® Knee CR fixed bearing AOX® Polyethylene (6mm thick polyethylene) wore significantly less than the SIGMA® Curved CR Fixed Bearing Total Knee System with XLK Polyethylene (8mm thick polyethylene) under severe, high kinematics, displacement controlled wear test.

ATTUNE Knee System White Paper - Cruciate Retaining FB Insert Wear

 

Bench top testing, cadaveric comparisons, & in vivo fluoroscopy all confirm that the Triathlon Knee femoral component & its single radius-of-curvature leads to a less stable knee joint where the optimized shape of the ATTUNE® Knee femoral component, which incorporates a gradually reducing radius, coupled with a tibial insert optimized to provide A/P stability while enabling rotational freedom, provides patients with an excellent level of knee stability throughout their range of motion.

ATTUNE Knee System - Stability in Total Knee Replacement White Paper

 

While total knee arthroplasty (TKA) has been established as a durable & effective operation, several problems continue to contribute to patient dissatisfaction. The ATTUNE GRADIUS® Curve features a continuously changing radius of curvature that reduces the abrupt transition from distal to posterior radii. The added stability imparted by this design has the potential to help improve knee kinematics as well as improve a patient’s sense of confidence, particularly in situations such as stair climbing.

ATTUNE Knee System - ATTUNE GRADIUS® Curve White Paper

 

Through proprietary technologies like the ATTUNE GRADIUS® Curve, LOGICLOCK® Tibial Base, & INTUITION Instruments, the ATTUNE Knee System provides surgeons with a CS (cruciate sacrificing) implant that maintains optimized kinematics for improved stability & motion when the PCL (posterior cruciate ligament) is absent.

ATTUNE Knee System - Cruciate Sacrificing Fixed Bearing White Paper

 

Maximizing tibial coverage while setting proper tibial rotation remains key to a successful knee replacement (TKR) outcome. Surgeons who are looking for a robust implant that decouples tibial rotation & maximizing coverage should consider the benefits of the ATTUNE® Rotating Platform Knee design.

Tibial Base Design Factors Affecting Tibial Coverage After Total Knee Arthroplasty: Symmetric vs Asymmetric

 

Patient Story

Meet Kittie

a retired teacher and principal who is passionate about cycling. She had both knees replaced with the ATTUNE® Knee to overcome arthritis pain.

Patient Journey

Meet Kittie, a bi-lateral ATTUNE Knee patient

Kittie is a retired teacher and principal, avid cyclist, and real ATTUNE Knee patient.

Pre-Surgery: Kittie experienced excruciating knee pain

Kittie learned that arthritis was the cause of knee pain that was making it difficult to stay active.

Decision Time: The moment Kittie decided to follow through with TKR

Kittie realized she needed to have her knee joints replaced in order to improve her quality of life.

Surgery: Kittie spoke with her surgeon about implant options

Kittie worked with her surgeon to ensure she received an implant that would suit her active lifestyle.

Rehabilitation: Kittie worked hard through rehabilitation to get back to doing what she loves

With physical therapy, Kittie was able to get back on her bike 9 weeks after surgery.

ATTUNE Knee System Patient Brochure

 

Share this brochure with your knee replacement patients to help them learn more about the features and benefits of the ATTUNE Knee System. Printed copies of this brochure are available from your DePuy Synthes Sales Representative.

Product Information

This surgical technique provides guidelines for the implantation of the ATTUNE Knee System Family of Knee Implants with the INTUITION® Instrumentation. Four configurations: Posterior Stabilized Fixed Bearing (PS FB), Posterior Stabilized Rotating Platform (PS RP), Cruciate Retaining Fixed Bearing (CR FB), & Cruciate Retaining Rotating Platform (CR RP).

ATTUNE Knee System Surgical Technique

 

Early results demonstrate clinical and economic value of the ATTUNE Knee System; a knee system that is advancing patient outcomes and is designed to meet the needs of a changing patient population, such as the young and active patient Overall, a knee system well-suited for a value-based healthcare environment Designed for range of motion and stability backed by extensive research and development and clinical outcomes.

ATTUNE Knee Evidence Video - Featuring Drs. Barrett, Fehring, Nunley, & Van Loon

 

Since the commercial launch in 2014, the ATTUNE Knee System has shown statistically significant improvements in multiple Patient Reported Outcome Measures (PROMs) compared to certain leading knee brands. Additional studies have demonstrated significant improvements in patellofemoral outcomes, including anterior knee pain, compared to another leading knee brand.

ATTUNE Knee System Value Brief

 

 

Share this brochure with your knee replacement patients to help them learn more about the features and benefits of the ATTUNE Knee System. Printed copies of this brochure are available from your DePuy Synthes Sales Representative.

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Understanding the FDA's MAUDE Database

This white paper describes the FDA’s MAUDE Database reporting requirements, and DePuy Synthes Companies multi-step process to reporting an Adverse Event to the MAUDE Database.

Since the commercial launch in 2014, the ATTUNE Knee System has shown statistically significant improvements in multiple Patient Reported Outcome Measures (PROMs) compared to certain leading knee brands. Additional studies have demonstrated significant improvements in patellofemoral outcomes, including anterior knee pain, compared to another leading knee brand.

Cementing Guidance for Total Knee Replacement

 

Article Reviews

This response to the Bonutti, et al. article, released in June 2017, includes our assessment of statements in the article, as well as provides a summary of the broader published clinical & registry data supporting the performance of the ATTUNE Knee System.

ATTUNE Knee Article Response to Bonutti et al (Full Response)

This response includes our assessment of statements in the article, as well as provides a summary of the broader published clinical and registry data supporting the performance of the ATTUNE Knee System.

Confidence in the ATTUNE® Knee is driven by real world scientific evidence. A response to the article titled “Unusually High Rate of Early Failure of Tibial Component in ATTUNE Total Knee Arthroplasty (TKA) System at Implant-Cement Interface.”

ATTUNE Knee Article Response to Bonutti et al (Condensed Response)

This condensed response includes a brief overview of our assessment of statements in the article, as well as provides a summary of the broader published clinical and registry data supporting the performance of the ATTUNE Knee System.

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Dr. Mont Letter to Editor

This one-pager provides links to the response from Dr. Mont to Bonutti, et al. and DePuy Synthes’ response.

Intraoperative kinematics study in Japanse women demonstrated that the ATTUNE Knee System provided improved kinematics (AP stability, reduced paradoxical anterior slide) compared to patients implanted with the SIGMA® Knee System.

Review of Dr. Takagi’s Case Series Report of ATTUNE Knee System

Case series report of navigation-based in vivo knee kinematics in total knee arthroplasty with a gradually reducing femoral radius design.

In the News

Press Releases

This study’s 2-year RSA (Radiostereometric Analysis), an imaging technique that precisely measures implant migration & can help predict implant survivorship, showed that the ATTUNE® Knee tibial base achieved stable fixation by demonstrating average micromotion of 0.17mm between one & two years. This is consistent with implants that have acceptable revision rates due to aseptic loosening.

Press Release of Powerful Imaging Technology Generates New Evidence on ATTUNE Knee System

Canadian RSA Network study shows stable fixation of the ATTUNE Knee at 2 years.

According to the analysis, the ATTUNE® Knee has thus far demonstrated favorable survivorship, improved patient reported outcome versus other knee systems, as well as potential economic benefits.

Press Release of the Clinical and Economic Value of the ATTUNE Knee System

Overview of analysis on the ATTUNE Knee System survivorship, economic and patient reported data to measure outcomes and cost benefits.

References

1. Indelli P.F., Pipino G., Johnson P., Graceffa A., Marcucci M. Posterior-stabilized total knee arthroplasty: a matched pair analysis of a classic and its evolutional design. Arthroplasty Today 2016; 206,2(4):193-1986. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

2. Ranawat C.S., White P.B., West S., Ranawat A.S., Clinical and Radiographic Results of Attune and PFC Sigma Knee Designs at 2-Year Follow-Up: A Prospective Matched-Pair Analysis. J Arthroplasty 2017;32:431-6. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

3. Martin J.R., Jennings J.M., Watters T.S., Levy D.L., McNabb D.C., Dennis D.A. Femoral Implant Design Modification Decreases the Incidence of Patellar Crepitus in Total Knee Arthroplasty. J Arthroplasty. 2017 Apr;32(4):1310-1313. Implants tested: P.F.C. SIGMA and ATTUNE Knee.

4.Toomey, S.D., Daccach, J., Shah, J., Himden, S., Lesko, J., Hamilton W.G.: Comparative Incidence of Patellofemoral Complications Between Two Total Knee Arthroplasty Systems in a Multi-Center, Prospective Clinical Study. J Arthroplasty, available online, April 2017. Implants tested: P.F.C. SIGMA (DePuy)

5. Hamilton W.G., Brenkel, I., Clatworthy, M., Dwyer, K,. Himden, S., Lesko, J., Kantor, S. Early Outcomes with a New Primary TKA System vs. Contemporary TKA: Interim Results of Two Worldwide, Multi-Center Prospective Studies. AAOS, San Diego, California, March 14-18, 2017. Other implants tested: SIGMA Knee (DePuy), NexGen® (Zimmer), Triathlon® (Stryker)

6. Clatworthy, M. (2015). An Early Outcome Study of the ATTUNE Knee System vs. the SIGMA® CR150 Knee System. DePuy Synthes Companies White Paper. DSUS/JRC/0814/0418(1). In an IRB approved early outcomes study, physiotherapists collected data on 40 patients implanted with ATTUNE® Knees and 40 patients with SIGMA®CR150 knees. The results demonstrated that patients implanted with the ATTUNE Knee had statistically significant improvements in some early outcomes, other outcomes demonstrated a trend favoring the ATTUNE Knee, and some outcomes were equivalent.

7. Etter, K., Lerner, J., de Moor, C, Yoo, A., Kalsekar, I. (2016). PMD10-Comparative Effectiveness of ATTUNE® Versus TriathlonTM Total Knee Systems: Real-World Length of Stay and Discharge Status.”Value in Health 19(3): A298. Premier PerspectiveTM Database analysis including 38 hospitals, representing 1,178 primary, unilateral TKAs with the ATTUNE Knee and 5,707 primary, unilateral TKAs with TriathlonTM. The analysis found that the patients implanted with the ATTUNE Knee had statistically shorter length of stay and were more frequently discharged home vs. a skilled nursing facility compared to the TKAs with TriathlonTM.

 

The ATTUNE Knee System is backed by a comprehensive evidence generation program that encompasses clinical and patient reported outcomes (PROMS) as well as value based healthcare studies.

The early clinical results of the ATTUNE Knee are promising and include data from national registries, company initiated, independent studies, and investigator initiated studies, as noted in the articles and papers.

 

All medical devices have associated risks. Please refer to the instructions for use and other labeling for a complete list of indications, contraindications, precautions and warnings.

For further information on DePuy Synthes products, please contact your local DePuy Synthes Representative .

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